98, no. W. L. Sacks, S. Bose, Z. S. Zumsteg et al., Impact of Afirma gene expression classifier on cytopathology diagnosis and rate of thyroidectomy, Cancer Cytopathology, vol. Therefore, the superiority of the GEC test lies in ruling-out of malignancy (higher sensitivity) and the ThyroSeq is a better test of ruling-in thyroid neoplasm (higher specificity). Fresh samples: Are to be refrigerated after 1hr of collection. Most nodules with benign pathological results and well-differentiated PTC are proliferated from thyroid follicular cells. The first version of ThyroSeq was launched for clinical use at the University of Pittsburgh Medical Center as a seven-gene panel (ThyroSeq v0) in April of 2007. Thus, the decision to operate should not be taken lightly. Steward DL, et al. And that turnaround time reduction of 20 hours represented significant savings for the Power Generation company. 760 Westchester Avenue, Suite 200, Rye Brook, NY 10573. Patients selection for surgery may affect both accuracy and clinical applicability of the test. All conflicts were resolved through consensus within the groups. 167.99.15.50 Because turnaround time is time in which a plant can't operate, which in turn means that it's time in which you are not able to make money. 2. Additionally, several molecular tests have demonstrated the ability to identify medullary thyroid cancer (MTC), an aggressive, but rare form of cancer that is often difficult to detect with cytopathology. Clinical utility data demonstrated that use of the 167-gene classifier changed patient care as intended. H. Gharib, E. Papini, R. Paschke et al., American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules, Journal of Endocrinological Investigation, vol. Effective leadership is critical to successful school turnaround efforts. Sustainable Development PerformanceRailingsTonnage received increased from 68.52 Mt in 2012 to 70.8Mt in 2013, the first time coal deliveries exceeded the 70 million mark.The key performance indicators were also exceeded as Train Turnaround Time (TTT) reached a record of 03:08. Yet, district leaders have historically been hesitant to hold leaders accountable for bold change efforts. As federal and state dollars flow to districts and individual schools charged with embarking upon transformative change efforts, districts must adopt a laser-sharp focus on assessing turnaround leaders' performance . Nullam dictum felis eu pede mollis pretium. Ensure any newtechnology that needs to be put in place works and is on-site, ready to be installed well in advance of the scheduled downtime. [emailprotected] (817) 735-2465 Learn more I get your point & understand the need for this order for you. 12, pp. 683691, 2017. At the end of the day, 10 were done and I wished I had more time (and energy!). G. Harrison, J. MetaDisc software was used to investigate the pooled sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curves. Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples. Pathological diagnoses at resection of Afirma results with cytological subtypes (N=225). 20, no. E. S. Cibas and S. Z. Ali, The 2017 bethesda system for reporting thyroid cytopathology, Thyroid, vol. How often do you hear someone say, "I wish I had more hours in a . J. Y. Kwak, I. Jung, J. H. Baek et al., Thyroid imaging reporting and data system for ultrasound features of thyroid nodules: multicentric korean retrospective study, Korean Journal of Radiology, vol. The histopathological results of the thyroidectomy specimen were the reference standard for the determination of benign or malignant nodules. Endocrin Pathol. Poster presented at: 87th Annual Meeting of the American Thyroid Association; October 2017; Victoria, BC, Canada. thyroseq turn around time. Every single minute a power plant is down represents a loss of potential profit, which means that every minute that can be cut off of a plants turnaround time represents money that the company has saved. We aimed to evaluate the diagnostic performance of Afirma gene expression classifier (GEC) for the indeterminate thyroid nodules (ITNs). In this meta-analysis, the pooled sensitivity of GEC was higher than our analysis while the pooled specificity was lower than our analysis. If you have a related question, please click the "Ask a related question" button in the top right corner.The newly created question will be automatically linked to this question. FLYABILITY SARoute du Lac 31094PaudexSwitzerland, USA:1001 Bannock St Suite 436Denver, CO 80204303-800-4611, China:200082 Shanghai, Yangpu District, Huoshan Road, No.398 EBA center T2, 3f, Room 121, Privacy PolicyDownload without providing email. Use cold pack for transport. The rate of informative results was higher in FNAs collected into preservative solution as compared to cytology smears (79-93% vs. 96%). The faster you can get your operations back online, the faster you can go back to making a profit. Several original articles missed part of the detailed pathological results of surgical samples, just described surgical results as benign or malignant. Thus, over half of nodules with GEC-suspicious results still require further validation like molecular markers, diagnostic surgery, or long follow-up, which limits its use in future clinical practice. Since the most benign nodules with GEC-suspicious results are follicular adenomas, benign follicular nodules and adenomatoid nodules, it is essential to combine other molecular markers to improve the specificity of GEC. saginaw spirit jersey. The benign thyroid nodules proved by surgical resection are follicular adenoma, benign follicular nodule and adenomatoid nodule, etc. Cloudflare monitors for these errors and automatically investigates the cause. All studies that were included in this systematic review stated to be in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. 867873, 2016. Patel K. Clinical Validation of an Improved Genomic Classifier for Cytologically Indeterminate Thyroid Nodules Using an NGS Platform and Machine Learning Algorithms in an Independent Prospective Multicenter Blinded Cohort Demonstrates Improved Performance. Anyone recently taken a rapid PCR (ID NOW) test at Walgreens? 15 jun. 11, pp. 5, pp. Time used by an airtanker or helitanker to reload and return to the fire. If you anticipate needing in-depth engineering work during a planned outage(or are having a turnaround just for this reason), here are some steps you can take to try and avoid unanticipated delays: Although plant turnarounds can be planned well in advance, this advance scheduling also needs to include communication with other departments in a plant or company. Summary receiver operating characteristic (SROC) curve with prediction and confidence contours. 6, pp. Moon, and J. Y. Kwak, Malignancy risk stratification of thyroid nodules: comparison between the thyroid imaging reporting and data system and the 2014 american thyroid association management guidelines, Radiology, vol. Furthermore, results from these add-on tools could point in the direction of a more personalized treatment strategy. thyroseq turn around time. The Web's largest and most authoritative acronyms and abbreviations resource. There is an issue between Cloudflare's cache and your origin web server. Alexander EK, et al. It was based on suspicious ultrasound features such as solid component, hypoechogenicity or marked hypoechogenicity, irregular margins, microcalcifications or mixed calcifications, and taller-than-wide shape. While mutational testing alone may not be enough to help the physician determine whether a patient requires surgery, it may help inform what type of surgery to perform. support@usimprints.com 866-604-6774 NOTICE - Many of our factories are experiencing extended production times. How to say ThyroSeq in English? Posted Apr 13, 2021. 99, no. (2)Lack of clinical characteristics of nodules, clear inclusion, and exclusion criteria. Sosa JA. Currently, he is a PhD student in Life Sciences Psychiatry at University Magna Graecia of Catanzaro (Italy). thyroseq turn around time - Funinsyou.jp We also used Cochrane Review Manager Version 5.3 (RevMan; 2014) to perform risk of bias evaluations of studies included in this meta-analysis. Aliquam lorem ante, dapibus in, viverra quis, feugiat a, tellus. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Vivamus elementum semper nisi. Cytopathology examination of ultrasound-guided fine needle aspiration (FNA) biopsies is the standard preoperative tool for evaluating thyroid nodules larger than one cm. Cancer Cytopathol. If you have a related question, please click the "Ask a related question" button in the top right corner.The newly created question will be automatically linked to this question. Furthermore Dr. Suresh Bada Math has 272 Published Scientific Articles in Indexed Journals and is editor of six books. Digital pathology is becoming a relevant tool in healthcare, industrial and research sectors to reduce the . This thread has been locked. X. Zeng, Y. Zhang, J. S. Kwong et al., The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review, Journal of Evidence-Based Medicine, vol. Bihui Pan took charge of data statistics and Li Xu extracted the parameters from each study. The time from arrival of an EMS unit at a hospital to its departure time. Shipping of shop items are 3 days after purchase. Sample: ID Created_EST Transport_Arrival_EST Exit_EST What is the completion time, turnaround time, and waiting time for First Come First Serve, Round Robin, Shortest Process Next, Shortest Remaining Time, Highest Response Ratio Next, and Multilevel Feedback for these set of arrival and service times? thyroseq turn around time - Dice-dental.asia Sign up to see the Elios 3 live in a location near you. By continuing to use this site you consent to our use of cookies. Due Apr 20, 2021. 25, 2017. I put records from second table in excel file for those who are using excel as tool for TAT solution. Meanwhile, 1371 of 1599 nodules categorized as suspicious GEC results underwent surgery; 617 (45.0%) of them were malignant while 754 (55.0%) were benign. Approximately 15 to 30% of thyroid nodules evaluated by fine-needle aspiration (FNA) were classified as indeterminate; the accurate diagnostic molecular tests of these nodules remain a challenge. Indeterminate thyroid results via FNA that included categories III, IV, and V. Histopathologic results diagnosis from thyroidectomy surgical specimens as gold reference standard. I put records from second table in excel file for those who are using excel as tool for TAT solution. Pre-operative knowledge of MTC enables the treating physician to anticipate potential complications such as life-threatening hypertension that can accompany MTC in the setting of multiple endocrine neoplasia type 2. Hi, Thank you for writing to us here about the order. Use cold pack for transport if necessary. Furthermore, results from these add-on tools could point in the direction of a more personalized treatment strategy. b. As federal and state dollars flow to districts and individual schools charged with embarking upon transformative change efforts, districts must adopt a laser-sharp focus on assessing turnaround leaders' performance . (3)Histopathologic results diagnosis from thyroidectomy surgical specimens as gold reference standard. High Point Central Athletics, Learn more I got my invite on 2/22 But didn't put in an order since I was worried I wouldn't get it on time before my vacation. L. Yip and J. This thread has been locked. His role in international psychiatry is highlighted by his current position as President of World Psychiatric Association (WPA). The mutation is detected in more than half of papillary thyroid cancer. The diagnostic application of RNA sequencing in patients with thyroid cancer: an analysis of 851 variants and 133 fusions in 524 genes. 13 days? We aimed to evaluate the diagnostic performance of Afirma gene expression classifier (GEC) for the indeterminate thyroid nodules (ITNs).<i> Methods</i>. 3500 Camp Bowie Boulevard Fort Worth, Texas 76107. Etiam sit amet orci eget eros faucibus tincidunt. hbspt.cta._relativeUrls=true;hbspt.cta.load(2602167, '38a8d069-cbeb-42ba-ab0e-e2eccda270ea', {"useNewLoader":"true","region":"na1"}); Flyability is a Swiss company building solutions for the inspection and exploration of indoor, inaccessible, and confined spaces. The performance of GEC could range widely between tertiary care facilities and comprehensive hospitals [9]. 892899, 2011. 2, p. 14, 2016. And 15ml Cytolyt, ethanol orformalin jar for needle rinse/cellblock Lab 949-824-6361 949-824-3033 (fax) Student Health Center Laboratory is open during Student Health Center's hours of operation. With hundreds of customers in over 50 countries in Power Generation, Oil & Gas, Chemicals, Maritime, Infrastructures & Utilities, and Public Safety, Flyability has pioneered and continues to lead the innovation in the commercial indoor drone space. catriona gray lava gown for sale; liverpool gangsters 2020 Haugen BR, et al. Since not all studies included cytological subtypes performance of with GEC results, we calculated nodules with cytological subtypes (N=1628), which are given in Table 2. J.-F. 6. The pooled sensitivity of GEC is 95.5% (95% CI 93.5%97.0%, I2 value 65.0%, p < 0.001), the pooled specificity is 22.1% (95% CI 19.4%-24.9%, I2 value 89.1%, p < 0.001), the PLR is 1.167 (95% CI 1.0881.252, I2 value 77.5%, p < 0.001), the NLR is 0.285 (95% CI 0.1990.410, I2 value 0.00%, p= 0.778), the NPV is 88.2% (95% CI 0.8330.921, I2 value 41.1%, p < 0.001), the PPV is 44.3% (95% CI 0.4160.471, I2 value 65.0%, p < 0.001), and the DOR is 5.25 (95% CI 3.428.04, I2 value 0.00%, Q 9.42, p=0.855). D. S. Duick, J. P. Klopper, J. C. Diggans et al., The impact of benign gene expression classifier test results on the endocrinologistpatient decision to operate on patients with thyroid nodules with indeterminate fine-needle aspiration cytopathology, Thyroid, vol. Nipple Discharge: 1-2 direct smears, spray fixed These patients may require a second surgery to complete the thyroidectomy. In enim justo, rhoncus ut, imperdiet a, venenatis vitae, justo. 119, no. In 2011 Davor Mucic launched Telemental Health Section within EPA (European Psychiatric Association). What is Turnaround time? 21,276 Turnaround Time jobs available on Indeed.com. Dr.Reem Alshareef is a family medicine resident PSY-3 at king Abdulaziz medical city, Jeddah ,Saudi Arabia. Absence of surgical histopathology results. Oversight can be key to efficiency during these times. HCNs partly contributed to the false positive rate of GEC. 21,276 Turnaround Time jobs available on Indeed.com. Singer J, et al. 2018. Simpler projects are quicker, more complex projects take longer. 11, pp. Browse the use examples 'turnaround time ,' in the great English corpus. These limitations in cytopathology have led to the emergence of molecular testing to provide cytopathologists and treating physicians with previously undetectable diagnostic information about patients thyroid nodules. I didn't want to be pushy if this was normal but it doesn't seem right. Lithwick-Yanai G, Dromi N, Shtabsky A, et al. Molecular testing is fast becoming the standard of care in evaluating thyroid nodules. We used a QUADAS-2 report [29] for the included studies to assess the bias and applicability of the test. Davor Mucic is a psychiatrist from Denmark with special interest in use of technology in provision of mental health care. Folks, How quick are aircraft refueled and more importantly, cleaned before the next flight. What Shops Are At The Valley Evesham, helensvale aquatic centre birthday parties, find the missing length of a parallelogram calculator, has lg fixed their compressor issues 2021, applied behavior analysis cooper 3rd edition pdf, a typical crash related to sleepiness quizlet, world war ii in the pacific map assignment, boat registration check western australia, hotels inside heathrow airport terminal 5, what does the shopping cart emoji mean on snapchat, loyola university medical center pharmacy residency, lord of ravaging dynasties 3 release date. Thyroid surgery can take a significant toll on patients, due to its morbidity, operative risks, and costs. Dr. Afzal Javed is a Consultant Psychiatrist & an Honorary Associate Clinical Professor, Mental Health & Wellbeing, Warwick Medical School, University of Warwick, UK. If a fresh FNA sample collected into ThyroSeqPreserve is not available or has failed ThyroSeq testing, cytology smears can be submitted for testing. Of 1187 benign nodules, 228 (19.2%) benign nodules underwent surgery; 27 (11.8%) of them proved to be malignant while 201 (88.2%) were benign after thyroidectomy. As a physician who has been managing patients with thyroid nodules for over 15 years, I believe the opportunity to provide excellent patient care has never been greater than it is now. An easy way to think of turnaround time is the time from the moment a request is made or a process is started to the time when the request is fulfilled or the process is complete. 4, pp. Testing based on these technologies is enabling physicians to better determine which patients can safely avoid surgery as part of their diagnostic work-up and make better surgical decisions for those patients who require it. Download scientific diagram | Truck Turnaround Time, Queueing time, and Service Time. 60, no. 705715, 2012. To help support the investigation, you can pull the corresponding error log from your web server and submit it our support team. Moved Permanently. We are always working! Jug R, et al. National Comprehensive Cancer Network. This thread has been locked. 141, no. As further evidence of molecular testings ubiquity, one need look no further than the 2017 ATA annual meeting in British Columbia, where nearly 30 presentations covered new ground on this topic. Needle rinse and designated pass into Cytolyt, ethanol or formalin for cell block preparation as needed. Because parathyroid cells often appear similar to atypical thyroid cells under the microscope, cytopathologists often designate them as indeterminate typically, as Bethesda III or IV. I get your point & understand the need for this order for you. Some studies supported that DTC patients with CLT had a better prognostic outcome compared with those without CLT [35]. Yet, district leaders have historically been hesitant to hold leaders accountable for bold change efforts. During planned downtimes, these are some of the most common types of turnaround work: In any setting, turnaround time equals money. Cras dapibus. 10-14 days is a typical turnaround time for a medium-low complexity projects. Ensure that the proper personnel will be present to do the work. Sample: ID Created_EST Transport_Arrival_EST Exit_EST Quality products made for your protection quickly! Furthermore, potential adverse effects of thyroid hormone therapy include cardiac arrhythmias and loss of calcium, raising the risk of osteopenia or osteoporosis. Some patients reported simply not feeling well after removal of all or part of their thyroid. The diagnostic profiling of GEC is mainly limited to papillary and follicular thyroid carcinoma partly due to the relatively low prevalence of medullary and anaplastic thyroid cancer. The present meta-analysis has summarized the previously reported performance of GEC. E. Brauner, B. J. Holmes, J. F. Krane et al., Performance of the afirma gene expression classifier in hrthle cell thyroid nodules differs from other indeterminate thyroid nodules, Thyroid, vol. Some molecular tests have also demonstrated the ability to distinguish parathyroid tissue from thyroid nodules. The same is true in cases of RET/PTC1 and RET/PTC3. Sosa JA, et al. 13 days? B. Celik, C. R. Whetsell, and A. Nassar, Afirma GEC and thyroid lesions: an institutional experience, Diagnostic Cytopathology, vol. Just checking a relative's scheduled flight from Bali to Dubai and see the same aircraft is en route from NZ to Bali. This type of molecular testing has been considered primarily as a rule in test for cancer due to its typically higher specificity for cancer, yet lower sensitivity. R. R. Lastra, M. R. Pramick, C. J. Crammer, V. A. LiVolsi, and Z. W. Baloch, Implications of a suspicious afirma test result in thyroid fine-needle aspiration cytology: an institutional experience, Cancer Cytopathology, vol. Each item is handmade, and turnaround time may depend on the complexit How often do you hear someone say, "I wish I had more hours in a . Reply. In the TBSRTC, the adenomatoid nodule is divided into category III or category IV [1]. 789796, 2015. Additional studies demonstrated the durability of a benign GEC result, as patients were followed clinically over an extended period of time and remained cancer free. J. P. Abeykoon, L. Mueller, F. Dong, A. V. Chintakuntlawar, J. Paludo, and R. Mortada, The effect of implementing gene expression classifier on outcomes of thyroid nodules with indeterminate cytology, Hormones and Cancer, vol. 11, pp. I got my invite on 2/22 But didn't put in an order since I was worried I wouldn't get it on time before my vacation. Is Nico De Boinville Married, Evaluation of ThyroSeq v2 performance in thyroid nodules with indeterminate cytology. We conducted Deeks funnel plot asymmetry test to evaluate publication bias in each section of the analysis (Figure 6). 33, no. The next-generation sequencing panel, ThyroSeq v2, detected 14 cancer gene mutations with more than 1000 hotspots and 42 types of gene fusions or rearrangements in thyroid cancer [45]. Oral presentation at: 87th Annual Meeting of the American Thyroid Association; October 2017; Victoria, BC, Canada. Our present data revealed that the pooled NPV of GEC was not as high as previous studies [7, 9, 32]. 9, pp. Nam eget dui. She has a doctor of Philosophy (Computer Engineering and Technology) Ph.D., a Master of Engineering (Computer) M.E. ThyroSeq Genomic Classifier (GC) is a test for the pre-operative assessment of thyroid nodules with indeterminate cytology, which offers accurate assessment of cancer probability in a given nodule and additionally provides information on cancer prognostication, helping to select the most optimal patient management. 74.6k members in the step1 community. Guidelines For Laundry In Healthcare Facilities, Pronunciation of ThyroSeq with 1 audio pronunciation and more for ThyroSeq. Ying Liu and Da Fang independently searched the database and Ying Liu drafted the manuscript. 3. 10-14 days is a typical turnaround time for a medium-low complexity projects. Service Desk. test utilizes next-generation sequencing to analyze DNA and RNA of 112 thyroid-related genes for four main classes of molecular alterations, including mutations, gene fusions, copy number alterations, and gene expression alterations, The results are processed by a unique Genomic Classifier (GC) and reported as Positive or Negative, Confidently rules out cancer and prevents unneeded surgeries in 61-67% of patients with indeterminate cytology nodules. Cold pack shouldnt come in direct contact with specimen. This period of time is often commonly called downtime, a planned outage, or a plant turnaround. Background. Table 4 shows the surgical pathological diagnoses at resection of Afirma results with cytological subtypes (with as much as available data) (N=225). E. Kay-Rivest, J. Tibbo, S. Bouhabel et al., The first Canadian experience with the Afirma gene expression classifier test, Journal of Otolaryngology - Head and Neck Surgery, vol. ; Burst time of a process can not be known in advance before executing the process. C.-C. C. Wang, L. Friedman, G. C. Kennedy et al., A large multicenter correlation study of thyroid nodule cytopathology and histopathology, Thyroid, vol. Because turnaround times can be so expensive, companies are constantly looking for ways to speed up their processes. The SROC curve has been shown in Figure 4 with prediction and confidence contours. In shipping, for example, the faster you can complete deliveries, the more deliveries you can make, and the more you profit. This is "ThyroSeq" by Stacey Rosenberg on Vimeo, the home for high quality videos and the people who love them. P1 waiting time = P1 turnaround time = P2 waiting time = P2 turnaround time = P3 waiting time = P3 turnaround time = 4. (a) the total waiting time for a process to finish execution (b) the total time spent in the ready queue (c) the total time spent in the running queue In up to 80 percent of cases, examination of cells collected with a fine needle from a suspicious lump in the thyroid, a gland in the front of the neck, typically can tell a pathologist whether it . Additional troubleshooting resources. Custom Orders TAT is 3-4 weeks after stitch out approval. Dr. Shank reported receiving research funding from Veracyle and he is on their speaker's bureau. A systematic review [30] which evaluated the methods of studies of GEC and concluded the most common methodologic drawback was lack of reference standard diagnosis analyses to unexcised ITNs with GEC-benign results, which resulted in overestimating the specificity. E1477E1483, 2015. Hence, identification of somatic alterations could provide insights to tumor biology and serve as an add-on diagnostic tool. Traditionally, most patients with cytologically indeterminate nodules have been referred for diagnostic surgery, even though 70% to 80% of these nodules ultimately prove to be benign by surgical histopathology meaning the surgery was unnecessary. Further, patients with confirmed thyroid cancer may not receive the surgery they need. 30, no. Mazzanti C et al, Using gene expression profiling to differentiate benign versus malignant thyroid tumors. thyroseq turn around time - Nexa.com.br Dr. Dipti D. Patil is working as Associate Professor in MKSSSs Cummins college of engineering for women, Pune from 26th December 2014 to till date. Table 6 shows the pooled sensitivity, specificity, confidence intervals and heterogeneity results of the test. Posted by: Category: Sem categoria . Incidental microcarcinomas were not included in the analysis. Sustainable Development PerformanceRailingsTonnage received increased from 68.52 Mt in 2012 to 70.8Mt in 2013, the first time coal deliveries exceeded the 70 million mark.The key performance indicators were also exceeded as Train Turnaround Time (TTT) reached a record of 03:08. should i warranty now or wait until after Xmas power supply fan started to make noise its not grinding or anything just sounds like a quiet clicking when it spins put eco mode on to help out with the noise also the current psu has 10yr warranty will the new one get the same warranty? The summary of final histopathologic subtypes of all samples are available in Table 5 (N=960). Since the I2 values of the sensitivity, specificity, PLR, and NPV were more than 50%, we conducted the metaregression analysis (inverse variance weights) to investigate the sources of heterogeneity. Approximately 15 to 30% of thyroid nodules evaluated by fine-needle aspiration (FNA) are classified as indeterminate, including atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS, category III), follicular neoplasm or suspicious for follicular neoplasm (FN/SFN, category IV), and suspicious for malignancy (SM, category V) according to the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) [1].
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